An essential amino acid
Related Products
Active Metabolite(s)
33458Imidazole Propionate
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Histidine

Item No. 33904

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-histidine
CAS Number
71-00-1
Synonyms
  • Glyoxaline-5-Alanine
  • NSC 137773
Molecular Formula
C6H9N3O2
Formula Weight
155.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 1 mg/ml
SMILES
OC([C@@H](N)CC1=CN=CN1)=O
InChi Code
InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1
InChi Key
HNDVDQJCIGZPNO-YFKPBYRVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    25 g

    $36

    Add

    50 g

    $61

    Add

    100 g

    $75

    Add

    500 g

    $236

    Add
    Product Description

    Histidine is an essential amino acid.1 It serves as a substrate for histidine decarboxylase (HDC) in the biosynthesis of histamine (Item No. 33828) and for carnosine synthase 1 in the biosynthesis of L-carnosine (Item No. 29825) and homocarnosine (Item No. 33695).1,2 Histidine (10-50 mM) scavenges hydroxyl radicals in cell-free assays.3 It inhibits biofilm formation by several strains of S. cerevisiae when used at a concentration of 10 mM.4 Histidine (100 mg/kg) decreases brain water content in a rat model of acute liver failure (ALF) induced by thioacetamide.5 Formulations containing histidine have been used as dietary supplements.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Holeček, M. Histidine in health and disease: Metabolism, physiological importance, and use as a supplement. Nutrients 12(3), 848 (2020).

    2. Skaper, S.D., Das, S., and Marshall, F.D. Some properties of a homocarnosine-carnosine synthetase isolated from rat brain. J. Neurochem. 21(6), 1429-1445 (1973).

    3. Zs-Nagy, I., and Floyd, R.A. Hydroxyl free radical reactions with amino acids and proteins studied by electron spin resonance spectroscopy and spin-trapping. Biochim. Biophys. Acta 790(3), 238-250 (1984).

    4. Zeidan, M.B., Zara, G., Viti, C., et al. L-Histidine inhibits biofilm formation and FLO11-associated phenotypes in Saccharomyces cerevisiae flor yeasts. PLoS One 9(11), e112141 (2014).

    5. Rao, K.V.R., Reddu, P.V.B., Tong, X., et al. Brain edema in acute liver failure: Inhibition by L-histidine. Am. J. Pathol. 176(3), 1400-1408 (2010).