An inhibitor of wild-type and mutant EGFR and HER2
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BDTX-189

Item No. 33932

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-7-[2-(4-morpholinyl)ethoxy]-6-quinazolinyl]-2-propenamide
CAS Number
2414572-47-5
Molecular Formula
C29H29ClN6O4
Formula Weight
561.0
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMF:PBS (pH 7.2) (1:2): 0.30 mg/mlDMSO: 1 mg/ml
λmax
253, 347 nm
SMILES
O=C(NC1=CC2=C(C=C1OCCN3CCOCC3)N=CN=C2NC4=CC(Cl)=C(OCC5=CC=CC=N5)C=C4)C=C
InChi Code
InChI=1S/C29H29ClN6O4/c1-2-28(37)35-25-16-22-24(17-27(25)39-14-11-36-9-12-38-13-10-36)32-19-33-29(22)34-20-6-7-26(23(30)15-20)40-18-21-5-3-4-8-31-21/h2-8,15-17,19H,1,9-14,18H2,(H,35,37)(H,32,33,34)
InChi Key
HIBPKFXWOPYJPZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

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    10 mg

    $293

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    25 mg

    $534

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    Product Description

    BDTX-189 is an inhibitor of wild-type and mutant EGFR and HER2 (IC50s = ≤30-500 and ≤10-100 nM, respectively).1 In vivo, BDTX-189 (30 and 50 mg/kg, twice daily) reduces tumor growth in a CUTO14 non-small cell lung cancer (NSCLC) mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Flohr, A., Mayweg, A., Trainor, G., et al. Quinazoline derivatives as tyrosine kinase inhibitor, compositions, methods of making them and their use. (2020).