A lipid excipient
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Alternative(s)
42746DMG-PEG(2000) (solution)
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DMG-PEG(2000)

Item No. 33945

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-[(2R)-2,3-bis[(1-oxotetradecyl)oxy]propyl]-ω-methoxy-poly(oxy-1,2-ethanediyl)
CAS Number
160743-62-4
Synonyms
  • 1,2-Dimyristoyl-rac-glycero-3-methoxy-Polyethylene Glycol(2000)
Molecular Formula
(C2H4O)nC32H62O5
Purity
≥90%
MW
2.5 kDa (Average)
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: Slightly solubleEthanol: 1 mg/ml
SMILES
COCCOCC(COC(CCCCCCCCCCCCC)=O)OC(CCCCCCCCCCCCC)=O
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 mg

    $152

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    1 g

    $273

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    Cayman Chemical
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    Product Description

    DMG-PEG(2000) is a lipid excipient that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs).1 Administration of fumarylacetoacetate hydrolase (FAH) mRNA in DMG-PEG(2000)-containing LNPs increases survival in a mouse model of hereditary tyrosinemia type 1 (HT-1). Formulations containing DMG-PEG(2000) have been used in the development of LNPs for the delivery of mRNA-based vaccines.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cheng, Q., Wei, T., Jia, Y., et al. Dendrimer-based lipid nanoparticles deliver therapeutic FAH mRNA to normalize liver function and extend survival in a mouse model of hepatorenal tyrosinemia type I. Adv. Mater. 30(52), e1805308 (2018).

    Product Citations

    Peña, Á., Heredero, J., Blandín, B., et al. Multicomponent thiolactone-based ionizable lipid screening platform for efficient and tunable mRNA delivery to the lungs. Commun. Chem. 8(1), 116 (2025).

    Mata, E., Broset, E., Matute, C., et al. Preserved efficacy of lyophilized SARS-CoV-2 mRNA vaccine incorporating novel ionizable lipids after one year at 25 °C. NPJ Vaccines 10(1), 135 (2025).

    Broset, E., Larraga, A., Lampaya, V., et al. A complete approach for circRNA therapeutics from purification to lyophilized delivery using novel ionizable lipids. Int. J. Mol. Sci. 26(11), 5138 (2025).

    Vinales, I., Silva-Espinoza , J.C., Medina, B.A., et al. Selective transfection of a transferrin receptor-expressing cell line with DNA-lipid nanoparticles. ACS Omega 9(38), 39533-39545 (2024).

    Yeo, S., Lee, H., Lee, J., et al. Optimization of polyethylene glycol shielding and mannose density on the lipid nanoparticles for efficient delivery to macrophages and spleens. Int. J. Pharm. 662, 124540 (2024).