An internal standard for the quantification of cinnarizine
Related Products
Unlabeled Version(s)
21001Cinnarizine
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Cinnarizine-d8

Item No. 33977

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(diphenylmethyl)-4-(3-phenyl-2-propen-1-yl)-piperazine-2,2,3,3,5,5,6,6-d8
CAS Number
1185242-27-6
Molecular Formula
C26H20D8N2
Formula Weight
376.6
Purity
≥99% deuterated forms (d1-d8)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Methanol: soluble
SMILES
[2H]C1([2H])C([2H])([2H])N(CC=CC2=CC=CC=C2)C([2H])([2H])C([2H])([2H])N1C(C3=CC=CC=C3)C4=CC=CC=C4
InChi Code
InChI=1S/C26H28N2/c1-4-11-23(12-5-1)13-10-18-27-19-21-28(22-20-27)26(24-14-6-2-7-15-24)25-16-8-3-9-17-25/h1-17,26H,18-22H2/i19D2,20D2,21D2,22D2
InChi Key
DERZBLKQOCDDDZ-HRSZNPPGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 µg

    $116

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    1 mg

    $197

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    5 mg

    $809

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    Product Description

    Cinnarizine-d8 is intended for use as an internal standard for the quantification of cinnarizine (Item No. 21001) by GC- or LC-MS. Cinnarizine is a calcium channel inhibitor and histamine H4 receptor antagonist (Ki = 142 nM).1,2,3 It inhibits L- and T-type calcium channels in isolated guinea pig atrial cells in a voltage-dependent manner.1 Cinnarizine inhibits L-type calcium currents in isolated guinea pig type II vestibular hair cells (IC50 = 1.5 µM). In vivo, cinnarizine (10 mg/kg) inhibits ethanol-induced gastric ulcer formation in rats.4 Formulations containing cinnarizine have been used in the treatment of nausea and vomiting due to vertigo, Meniere's disease, or chemotherapy.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cohen, C.J., Spires, S., and Van Skiver, D. Block of T-type Ca channels in guinea pig atrial cells by antiarrhythmic agents and Ca channel antagonists. J. Gen. Physiol. 100(4), 703-728 (1992).

    2. Arab, S.F., Düwel, P., Jüngling, E., et al. Inhibition of voltage-gated calcium currents in type II vestibular hair cells by cinnarizine. Naunyn Schmiedebergs Arch. Pharmacol. 369(6), 570-575 (2004).

    3. Nguyen, T., Shapiro, D.A., George, S.R., et al. Discovery of a novel member of the histamine receptor family. Mol. Pharmacol. 59(3), 427-433 (2001).

    4. Lozeva, V., Marazova, K., and Belcheva, A. Gastric histamine content and ulcer formation in rats with ethanol-induced injury. Effects of cinnarizine and flunarizine. Agents Actions 41 Spec No, C91-C92 (1994).