An internal standard for the quantification of phenylbutazone
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Unlabeled Version(s)
70400Phenylbutazone
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Phenylbutazone-d9

Item No. 33978

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(butyl-d9)-1,2-diphenyl-3,5-pyrazolidinedione
CAS Number
1189479-75-1
Molecular Formula
C19H11D9N2O2
Formula Weight
317.4
Purity
≥99% deuterated forms (d1-d9)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Soluble
SMILES
O=C1C(C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])C(N(C2=CC=CC=C2)N1C3=CC=CC=C3)=O
InChi Code
InChI=1S/C19H20N2O2/c1-2-3-14-17-18(22)20(15-10-6-4-7-11-15)21(19(17)23)16-12-8-5-9-13-16/h4-13,17H,2-3,14H2,1H3/i1D3,2D2,3D2,14D2
InChi Key
VYMDGNCVAMGZFE-ABVHXWLASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $134

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    1 mg

    $213

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    5 mg

    $729

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    Product Description

    Phenylbutazone-d9 is intended for use as an internal standard for the quantification of phenylbutazone (Item No. 70400) by GC- or LC-MS. Phenylbutazone is a non-steroidal anti-inflammatory drug and an inhibitor of the peroxidase activity of COX (IC50 = ~100 µM in the presence of hydrogen peroxide).1 It also inhibits prostaglandin I synthase (IC50 = ~25 µM in the presence of hydrogen peroxide). Phenylbutazone (2 mg/kg) reduces increases in type II collagen levels in the inflamed joints of an equine model of LPS-induced acute synovitis.2 Formulations containing phenylbutazone have been used in the treatment of lameness in horses.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Reed, G.A., Griffin, I.O., and Eling, T.E. Inactivation of prostaglandin H synthase and prostacyclin synthase by phenylbutazone. Requirement for peroxidative metabolism. Mol. Pharmacol. 27(1), 109-114 (1985).

    2. de Grauw, J.C., van Loon, J.P.A.M., van de Lest, C.H.A., et al. In vivo effects of phenylbutazone on inflammation and cartilage-derived biomarkers in equine joints with acute synovitis. Vet. J. 201(1), 51-56 (2014).