An NSAID and COX inhibitor
Related Products
Active Metabolite(s)
18723Oxyphenbutazone
Labeled Version(s)
33978Phenylbutazone-d9
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Phenylbutazone

Item No. 70400

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-butyl-1,2-diphenyl-3,5-pyrazolidinedione
CAS Number
50-33-9
Molecular Formula
C19H20N2O2
Formula Weight
308.4
Purity
≥99%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlEthanol: 50 mg/mlH2O: 1 mg/mlPBS pH 7.2: .5 mg/ml
λmax
242 nm
SMILES
CCCCC1C(=O)N(c2ccccc2)N(c2ccccc2)C1=O
InChi Code
InChI=1S/C19H20N2O2/c1-2-3-14-17-18(22)20(15-10-6-4-7-11-15)21(19(17)23)16-12-8-5-9-13-16/h4-13,17H,2-3,14H2,1H3
InChi Key
VYMDGNCVAMGZFE-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $17

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    50 g

    $63

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    Product Description

    Phenylbutazone is a non-steroidal anti-inflammatory drug and an inhibitor of the peroxidase activity of COX (IC50 = ~100 µM in the presence of hydrogen peroxide).1 It also inhibits prostaglandin I synthase (IC50 = ~25 µM in the presence of hydrogen peroxide). Phenylbutazone (2 mg/kg) reduces increases in type II collagen levels in the inflamed joints of an equine model of LPS-induced acute synovitis.2 Formulations containing phenylbutazone have been used in the treatment of lameness in horses.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Reed, G.A., Griffin, I.O., and Eling, T.E. Inactivation of prostaglandin H synthase and prostacyclin synthase by phenylbutazone. Requirement for peroxidative metabolism. Mol. Pharmacol. 27(1), 109-114 (1985).

    2. de Grauw, J.C., van Loon, J.P.A.M., van de Lest, C.H.A., et al. In vivo effects of phenylbutazone on inflammation and cartilage-derived biomarkers in equine joints with acute synovitis. Vet. J. 201(1), 51-56 (2014).