A conotoxin and an antagonist of α7 nAChRs
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α-Conotoxin ImI (trifluoroacetate salt)

Item No. 34022

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
glycyl-L-cysteinyl-L-cysteinyl-L-seryl-L-α-aspartyl-L-prolyl-L-arginyl-L-cysteinyl-L-alanyl-L-tryptophyl-L-arginyl-L-cysteinamide, cyclic (2→8),(3→12)-bis(disulfide), trifluoroacetate salt
Synonyms
  • α-CTx ImI
  • GCCSDPRCAWRC
Molecular Formula
C52H78N20O15S4 • XCF3COOH
Formula Weight
1351.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: soluble
SMILES
O=C(N[C@H](C(N[C@@H](CSSC[C@@H]1NC([C@H](CSSC[C@@H](NC([C@@H](NC([C@@]2([H])N(CCC2)C([C@@H](NC([C@@H](NC1=O)CO)=O)CC(O)=O)=O)=O)CCCNC(N)=N)=O)C(N[C@H](C(N3)=O)C)=O)NC(CN)=O)=O)C(N)=O)=O)CCCNC(N)=N)[C@@H]3CC4=CNC5=CC=CC=C45.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C52H78N20O15S4.C2HF3O2/c1-24-41(78)66-30(15-25-18-61-27-8-3-2-7-26(25)27)44(81)64-28(9-4-12-59-51(55)56)42(79)69-33(40(54)77)20-88-90-23-36-48(85)68-32(19-73)45(82)67-31(16-39(75)76)50(87)72-14-6-11-37(72)49(86)65-29(10-5-13-60-52(57)58)43(80)70-35(46(83)62-24)22-91-89-21-34(47(84)71-36)63-38(74)17-53;3-2(4,5)1(6)7/h2-3,7-8,18,24,28-37,61,73H,4-6,9-17,19-23,53H2,1H3,(H2,54,77)(H,62,83)(H,63,74)(H,64,81)(H,65,86)(H,66,78)(H,67,82)(H,68,85)(H,69,79)(H,70,80)(H,71,84)(H,75,76)(H4,55,56,59)(H4,57,58,60);(H,6,7)/t24-,28-,29-,30-,31-,32-,33-,34-,35+,36-,37-;/m0./s1
InChi Key
NREYMWYWHSLVEI-BXFPKOBISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    α-Conotoxin ImI is a conotoxin that has been found in C. imperialis and has receptor antagonist and anticancer activities.1 It is a peptide antagonist of homomeric α7 nicotinic acetylcholine receptors (nAChRs; IC50 = 220 nM). α-Conotoxin ImI is selective for α7 nAChRs over α2β2, α3β2, α4β2, α2β4, α3β4, α4β4, and α1β1γδ subunit-containing nAChRs at 5 µM but does inhibit homomeric α9 nAChRs (IC50 = 1,800 nM). Administration of paclitaxel (Item No. 10461) in micelles containing α-conotoxin ImI decreases tumor growth in an MCF-7 mouse xenograft model.2 Intracerebroventricular, but not intraperitoneal, administration of α-conotoxin ImI (20 nmol/animal) induces seizures in rats.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Johnson, D.S., Martinez, J., Elgoyhen, A.B., et al. α-Conotoxin ImI exhibits subtype-specific nicotinic acetylcholine receptor blockade: Preferential inhibition of homomeric α7 and α9 receptors. Mol. Pharmacol. 48(2), 194-199 (1995).

    2. Mei, D., Lin, Z., Fu, J., et al. The use of α-conotoxin ImI to actualize the targeted delivery of paclitaxel micelles to α7 nAChR-overexpressing breast cancer. Biomaterials 42, 52-65 (2015).

    3. McIntosh, J.M., Yoshikami, D., Mahe, E., et al. A nicotinic acetylcholine receptor ligand of unique specificity, α-conotoxin ImI. The Journal of Biological Chemisty 269(24), 16733-16739 (1994).