An inhibitor of USP14
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IU1-47

Item No. 34095

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-piperidinyl)-ethanone
CAS Number
670270-31-2
Molecular Formula
C19H23ClN2O
Formula Weight
330.9
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:3): 0.25 mg/mlDMSO: 10 mg/mlEthanol: 20 mg/ml
λmax
251 nm
SMILES
ClC1=CC=C(C=C1)N2C(C)=CC(C(CN3CCCCC3)=O)=C2C
InChi Code
InChI=1S/C19H23ClN2O/c1-14-12-18(19(23)13-21-10-4-3-5-11-21)15(2)22(14)17-8-6-16(20)7-9-17/h6-9,12H,3-5,10-11,13H2,1-2H3
InChi Key
VXQIPRWKLACSKZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $90

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    10 mg

    $168

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    25 mg

    $392

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    Cayman Chemical
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    Product Description

    IU1-47 is an inhibitor of ubiquitin-specific protease 14 (USP14; IC50 = 0.6 µM).1 It is selective for USP14 over USP5 (IC50 = 20 µM). IU1-47 increases degradation of a ubiquitinated proteasome substrate in a cell-free assay. It reduces tau levels in wild-type mouse embryonic fibroblasts (MEFs) expressing human tau but not Usp14-null MEFs expressing human tau. IU1-47 (25 µM) reduces tau levels in primary rat cortical neurons. It also decreases migration of, and increases autophagy in, A549 and H1299 cancer cells.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Boselli, M., Lee, B.-H., Robert, J., et al. An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons. The Journal of Biological Chemisty 292(47), 19209-19225 (2017).

    2. Han, K.H., Kwak, M., Lee, T.H., et al. USP14 inhibition regulates tumorigenesis by inducing autophagy in lung cancer in vitro. Int. J. Mol. Sci. 20(21), 5300 (2019).