A CK2α inhibitor
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SGC-CK2-1

Item No. 34103

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[5-[[3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl]amino]-2-methylphenyl]-propanamide
CAS Number
2470424-39-4
Synonyms
  • SGC-Casein Kinase 2-1
Molecular Formula
C20H21N7O
Formula Weight
375.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly solubleDMSO: Soluble
SMILES
N#CC1=C(N=C(NC2=CC=C(C)C(NC(CC)=O)=C2)C=C3NC4CC4)N3N=C1
InChi Code
InChI=1S/C20H21N7O/c1-3-19(28)25-16-8-15(5-4-12(16)2)23-17-9-18(24-14-6-7-14)27-20(26-17)13(10-21)11-22-27/h4-5,8-9,11,14,24H,3,6-7H2,1-2H3,(H,23,26)(H,25,28)
InChi Key
YKDZIFFKQUNVHH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $32

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    5 mg

    $128

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    10 mg

    $176

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    25 mg

    $400

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    Product Description

    SGC-CK2-1 is an inhibitor of casein kinase 2α (CK2α; IC50s = 4.2 and 2.3 nM for the catalytic subunits CK2α and CK2α’, respectively).1 It is selective for CK2α over DYRK2, Plk4, MEK5, and HIPK1, -2, and -3 (IC50s = 440, >10,000, 1,000, 3,700, 3,400, and 8,100 nM, respectively). SGC-CK2-1 (0.01-10 µM) decreases phosphorylation of Akt in HCT116 cells. See the Structural Genomics Consortium (SGC) website for more information.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wells, C.I., Drewry, D.H., Pickett, J.E., et al. Development of a potent and selective chemical probe for the pleiotropic kinase CK2. Cell Chem. Biol. 28(4), 546-558 (2021).