A multi-kinase inhibitor
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Sulfatinib

Item No. 34206

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-(dimethylamino)ethyl]-3-[[4-[(2-methyl-1H-indol-5-yl)oxy]-2-pyrimidinyl]amino]-benzenemethanesulfonamide
CAS Number
1308672-74-3
Synonyms
  • HMPL-012
Molecular Formula
C24H28N6O3S
Formula Weight
480.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:7): 0.12 mg/mlDMSO: 10 mg/mlEthanol: 1 mg/ml
λmax
220, 273 nm
SMILES
O=S(NCCN(C)C)(CC1=CC(NC2=NC=CC(OC3=CC4=C(NC(C)=C4)C=C3)=N2)=CC=C1)=O
InChi Code
InChI=1S/C24H28N6O3S/c1-17-13-19-15-21(7-8-22(19)27-17)33-23-9-10-25-24(29-23)28-20-6-4-5-18(14-20)16-34(31,32)26-11-12-30(2)3/h4-10,13-15,26-27H,11-12,16H2,1-3H3,(H,25,28,29)
InChi Key
TTZSNFLLYPYKIL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Sulfatinib is a multi-kinase inhibitor.1 It inhibits the receptor tyrosine kinases VEGFR1, VEGFR2, VEGFR3, FGFR1, colony stimulating factor 1 receptor (CSF1R), tropomyosin-related kinase B (TrkB), and FMS-related tyrosine kinase 3 (FLT3; IC50s = 2, 24, 1, 15, 4, 41, and 67 nM, respectively). It is selective for these kinases over a panel of 278 kinases (IC50s = >150 nM for all).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Qi, C., and Xu, J. Method of treating solid tumors. WO2018090324A1, (2018).