An internal standard for the quantification of carbinoxamine
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Unlabeled Version(s)
23937Carbinoxamine (maleate)
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Carbinoxamine-d6 (maleate)

Item No. 34246

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(4-chlorophenyl)-2-pyridinylmethoxy]-N,N-di(methyl-d3)-ethanamine, (2Z)-2-butenedioate
CAS Number
2747914-08-3
Molecular Formula
C16H13ClD6N2O • C4H4O4
Formula Weight
412.9
Purity
≥99% deuterated forms (d1-d6)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: solubleDMSO: soluble
SMILES
ClC(C=C1)=CC=C1C(OCCN(C([2H])([2H])[2H])C([2H])([2H])[2H])C2=CC=CC=N2.OC(/C=C\C(O)=O)=O
InChi Code
InChI=1S/C16H19ClN2O.C4H4O4/c1-19(2)11-12-20-16(15-5-3-4-10-18-15)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-10,16H,11-12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/i1D3,2D3;
InChi Key
GVNWHCVWDRNXAZ-QPEHKQNOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $148

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    5 mg

    $657

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    Product Description

    Carbinoxamine-d6 is intended for use as an internal standard for the quantification of carbinoxamine (Item No. 23937) by GC- or LC-MS. Carbinoxamine is a competitive histamine H1 receptor antagonist (Ki = 2.3 nM) and first generation antihistamine.1 It is also an L-type calcium channel inhibitor (Ki = 1.08 nM).2 Carbinoxamine decreases negative inotropic activity in isolated guinea pig left atria and negative chronotropic activity in guinea pig spontaneously beating isolated right atria (EC50s = 250 and 480 nM, respectively). Formulations containing carbinoxamine have been used in the treatment of allergic rhinitis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tran, V.T., Chang, R.S.L., and Snyder, S.H. Histamine H1 receptors identified in mammalian brain membranes with [3H]mepyramine. Proc. Natl. Acad. Sci. USA 75(12), 6290-6294 (1978).

    2. Carosati, E., Budriesi, R., Ioan, P., et al. Discovery of novel and cardioselective diltiazem-like calcium channel blockers via virtual screening. J. Med. Chem. 51(18), 5552-5565 (2008).