An irreversible DPD inhibitor
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Eniluracil

Item No. 34251

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-ethynyl-2,4(1H,3H)-pyrimidinedione
CAS Number
59989-18-3
Synonyms
  • 776C85
  • 5-Ethynyluracil
  • NSC 687296
Molecular Formula
C6H4N2O2
Formula Weight
136.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 25 mg/mlDMSO:PBS (pH 7.2) (1:7): 0.12 mg/ml
λmax
225, 285 nm
SMILES
O=C1NC=C(C(N1)=O)C#C
InChi Code
InChI=1S/C6H4N2O2/c1-2-4-3-7-6(10)8-5(4)9/h1,3H,(H2,7,8,9,10)
InChi Key
JOZGNYDSEBIJDH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    10 mg

    $48

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    25 mg

    $107

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    50 mg

    $154

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    100 mg

    $190

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    Cayman Chemical
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    Product Description

    Eniluracil is an irreversible inhibitor of dihydropyrimidine dehydrogenase (DPD; Ki = 1.6 µM), the rate-determining enzyme in the catabolism of pyrimidines, including 5-fluorouracil (Item No. 14416).1,2 It inhibits liver DPD and elevates plasma pyrimidine levels in rats (ED50s = 1.8 and 10 µg/kg, respectively).2 Eniluracil (2 mg/kg) potentiates the antitumor effects of 5-fluorouracil in MC-38 murine colon carcinoma and MOPC 315 murine myeloma models.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Porter, D.J., Chestnut, W.G., Merrill, B.M., et al. Mechanism-based inactivation of dihydropyrimidine dehydrogenase by 5-ethynyluracil. The Journal of Biological Chemisty 267(8), 5236-5242 (1992).

    2. Baccanari, D.P., Davis, S.T., Knick, V.C., et al. 5-Ethynyluracil (776C85): A potent modulator of the pharmacokinetics and antitumor efficacy of 5-fluorouracil. Proc. Natl. Acad. Sci. USA 90(23), 11064-11068 (1993).