An inhibitor of MAO-B
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PF 9601N

Item No. 34258

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(phenylmethoxy)-N-2-propyn-1-yl-1H-indole-2-methanamine
CAS Number
133845-63-3
Molecular Formula
C19H18N2O
Formula Weight
290.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:3): 0.25 mg/mlEthanol: 20 mg/ml
SMILES
C#CCNCC1=CC2=C(N1)C=CC(OCC3=CC=CC=C3)=C2
InChi Code
InChI=1S/C19H18N2O/c1-2-10-20-13-17-11-16-12-18(8-9-19(16)21-17)22-14-15-6-4-3-5-7-15/h1,3-9,11-12,20-21H,10,13-14H2
InChi Key
YFPNAYXYKXAKJC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $121

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    10 mg

    $215

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    25 mg

    $329

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    50 mg

    $597

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    Product Description

    PF 9601N is an inhibitor of monoamine oxidase B (MAO-B).1 It selectively inhibits MAO-B in mouse brain homogenates ex vivo (ID50 = 381 nmol/kg) and prevents MPTP-induced reductions in dopamine levels in the striatum of 8- to 9-week-old mice when administered at doses ranging from 29.5 to 8.47 µmol/kg. PF 9601N (0.027 µmol/kg) prevents MPTP-induced lesions in 9- to 10-month-old mice. It also increases the duration of contralateral rotational behavior induced by L-DOPA (Item No. 13248) in a rat model of Parkinson’s disease induced by 6-OHDA (Item No. 25330) when administered at doses of 40 and 60 mg/kg.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Perez, V., and Unzeta, M. PF 9601N [N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine], a new MAO-B inhibitor, attenuates MPTP-induced depletion of striatal dopamine levels in C57/BL6 mice. Neurochem. Int. 42(3), 221-229 (2003).

    2. Prat, G., Pérez, V., Rubi, A., et al. The novel type B MAO inhibitor PF9601N enhances the duration of L-DOPA-induced contralateral turning in 6-hydroxydopamine lesioned rats. J. Neural Transm. (Vienna) 107(4), 409-417 (2000).