An active metabolite of brinzolamide
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N-desethyl Brinzolamide (oxalate)

Item No. 34275

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4R)-4-amino-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide, 1,1-dioxide, monoethanedioate
CAS Number
2775292-24-3
Synonyms
  • AL 8520
Molecular Formula
C10H17N3O5S3 • C2H2O4
Formula Weight
445.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
255 nm
SMILES
COCCCN(S1(=O)=O)C[C@H](N)C2=C1SC(S(=O)(N)=O)=C2.OC(C(O)=O)=O
InChi Code
InChI=1S/C10H17N3O5S3.C2H2O4/c1-18-4-2-3-13-6-8(11)7-5-9(20(12,14)15)19-10(7)21(13,16)17;3-1(4)2(5)6/h5,8H,2-4,6,11H2,1H3,(H2,12,14,15);(H,3,4)(H,5,6)/t8-;/m0./s1
InChi Key
SADPWQTWTRQXLQ-QRPNPIFTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $63

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    5 mg

    $229

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    10 mg

    $423

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    25 mg

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    Product Description

    N-desethyl Brinzolamide is an active metabolite of the carbonic anhydrase (CA) inhibitor brinzolamide (Item No. 11660).1 It inhibits CAII and CAIV activities (IC50s = 1.28 and 128 nM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kim, C.-Y., Whittington, D.A., Chang, J.S., et al. Structural aspects of isozyme selectivity in the binding of inhibitors to carbonic anhydrases II and IV. J. Med. Chem. 45(4), 888-893 (2002).