An inhibitor of the METTL3/14 complex
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STM2457

Item No. 34280

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[[6-[[(cyclohexylmethyl)amino]methyl]imidazo[1,2-a]pyridin-2-yl]methyl]-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxamide
CAS Number
2499663-01-1
Molecular Formula
C25H28N6O2
Formula Weight
444.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: Slightly solubleDMSO: Slightly solubleEthanol: Slightly soluble
λmax
225 nm
SMILES
O=C1C=C(C(NCC2=CN3C=C(CNCC4CCCCC4)C=CC3=N2)=O)N=C5C=CC=CN15
InChi Code
InChI=1S/C25H28N6O2/c32-24-12-21(29-23-8-4-5-11-31(23)24)25(33)27-15-20-17-30-16-19(9-10-22(30)28-20)14-26-13-18-6-2-1-3-7-18/h4-5,8-12,16-18,26H,1-3,6-7,13-15H2,(H,27,33)
InChi Key
OBERVORNENYOLE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $91

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    10 mg

    $171

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    25 mg

    $379

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    Cayman Chemical
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    Product Description

    STM2457 is an inhibitor of the methyltransferase-like 3 (METTL3) and METTL14 complex (IC50 = 16.9 µM).1 It inhibits growth in a panel of acute myeloid leukemia (AML) cell lines (IC50s = 0.6-10.3 µM). STM2457 also inhibits the proliferation, migration, and invasion of HuCC-T1 and HCCC-9810 intrahepatic cholangiocarcinoma (ICC) cells in a concentration-dependent manner.2 It increases survival in a patient-derived xenograft (PDX) mouse model of AML when administered at a dose of 50 mg/kg.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yankova, E., Blackaby, W., Albertella, M., et al. Small molecule inhibition of METTL3 as a strategy against myeloid leukaemia. Nature 593(7860), 597-601 (2021).

    2. Xu, Q.-C., Tien, Y.-C., Shi, Y.-H., et al. METTL3 promotes intrahepatic cholangiocarcinoma progression by regulating IFIT2 expression in an m6A-YTHDF2-dependent manner. Oncogene 41(11), 1622-1633 (2022).