An inhibitor of IL-2 production
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SU 5201

Item No. 34333

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[(3,4-dichlorophenyl)methylene]-1,3-dihydro-2H-indol-2-one
CAS Number
114727-43-4
Synonyms
  • NSC 247030
Molecular Formula
C15H9Cl2NO
Formula Weight
290.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:2): 0.3 mg/mlDMSO: 20 mg/ml
λmax
255, 326 nm
SMILES
O=C1NC2=C(C1=CC3=CC(Cl)=C(C=C3)Cl)C=CC=C2
InChi Code
InChI=1S/C15H9Cl2NO/c16-12-6-5-9(8-13(12)17)7-11-10-3-1-2-4-14(10)18-15(11)19/h1-8H,(H,18,19)
InChi Key
RCJZXLNWNCVIMJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $134

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    100 mg

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    500 mg

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    Product Description

    SU 5201 is an inhibitor of IL-2 production.1 It inhibits IL-2 production in peripheral blood mononuclear cells (PBMCs) with an IC50 value of 1 nM. SU 5201 also inhibits VEGF- or acidic FGF-induced proliferation of human umbilical vein endothelial cells (HUVECs) when used at concentrations of 2.5 and 2.3 µM, respectively.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bouert, E.M.L., Fensholdt, J., Nielsen, S.F., et al. Novel therapeutic use of indolinone derivatives. (2005).

    2. Masferrer, J.L., Cherrington, J.M., Leahy, K.M., et al. Methods using a combination of a 3-heteroaryl-2-indolinone and a cyclooxygenase-2 inhibitor for the treatment of neoplasia. (2003).