A lipid excipient
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Product Categories

Product Type

Biochemicals
Lipid Nanoparticles (LNPs)
PEGylated Lipids
Lipids

Research Area

ALC-0159

Item No. 34336

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-[2-(ditetradecylamino)-2-oxoethyl]-ω-methoxy-poly(oxy-1,2-ethanediyl)
CAS Number
1849616-42-7
Synonyms
  • N,N-ditetradecylacetamide PEG(2000)
  • N,N-ditetradecylacetamide Polyethylene Glycol-2000
Molecular Formula
(C2H4O)nC31H63NO2
Purity
≥95%
MW
Average: 2400 Da
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS (pH 7.2) (1:2): 0.3 mg/mlDMSO: Slightly SolubleEthanol: 1 mg/ml
SMILES
COCCOCC(N(CCCCCCCCCCCCCC)CCCCCCCCCCCCCC)=O
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $105

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    50 mg

    $189

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    100 mg

    $315

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    500 mg

    $945

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    Cayman Chemical
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    Product Description

    ALC-0159 is a lipid excipient.1 Formulations containing ALC-0159 have been used in the development of lipid nanoparticles (LNPs) for the delivery of mRNA-based vaccines.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cortés, H., Hernández-Parra, H., Bernal-Chávez, S.A., et al. Non-ionic surfactants for stabilization of polymeric nanoparticles for biomedical uses. Materials (Basel) 14(12), 3197 (2021).

    Product Citations

    Han, E.L., Kim, D., Murray, A.M., et al. High-throughput in vivo screening identifies structural factors driving mRNA lipid nanoparticle delivery to the brain. ACS Nano 20(4), 3807-3820 (2026).

    Mata, E., Broset, E., Matute, C., et al. Preserved efficacy of lyophilized SARS-CoV-2 mRNA vaccine incorporating novel ionizable lipids after one year at 25 °C. NPJ Vaccines 10(1), 135 (2025).

    Wojcechowskyj, J.A., Jong, R.M., Mäger, I., et al. Controlling reactogenicity while preserving immunogenicity from a self-amplifying RNA vaccine by modulating nucleocytoplasmic transport. NPJ Vaccines 10(1), 85 (2025).