A metabolite of 6-mercaptopurine
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6-Methylmercaptopurine

Item No. 34356

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-(methylthio)-9H-purine
CAS Number
50-66-8
Synonyms
  • 6-MMP
  • 6-(Methylthio)purine
  • NSC 20105
  • SQ 8,343
Molecular Formula
C6H6N4S
Formula Weight
166.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 30 m/gml
λmax
218, 289 nm
SMILES
CSC1=C2NC=NC2=NC=N1
InChi Code
InChI=1S/C6H6N4S/c1-11-6-4-5(8-2-7-4)9-3-10-6/h2-3H,1H3,(H,7,8,9,10)
InChi Key
UIJIQXGRFSPYQW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    50 mg

    $41

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    100 mg

    $75

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    250 mg

    $128

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    1 g

    $427

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    Product Description

    6-Methylmercaptopurine (6-MMP) is a metabolite of the purine synthesis and interconversion inhibitor 6-mercaptopurine (6-MP; Item No. 23675).1 It is formed from 6-MP via methylation by thiopurine S-methyltransferase. Levels of 6-MMP are increased in patients with altered thiopurine metabolism and associated with therapeutic resistance to 6-MP.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rieder, M.J., and Carleton, B. Pharmacogenomics and adverse drug reactions in children. Front. Genet. 5, 78 (2014).

    2. van Egmond, R., Chin, P., Zhang, M., et al. High TPMT enzyme activity does not explain drug resistance due to preferential 6-methylmercaptopurine production in patients on thiopurine treatment. Aliment. Pharmacol. Ther. 35(10), 1181-1189 (2012).