An antagonist of group II and group III mGluRs
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CPPG

Item No. 34362

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-amino-α-cyclopropyl-4-phosphono-benzeneacetic acid
CAS Number
183364-82-1
Synonyms
  • α-Cyclopropyl-4-phosphonophenylglycine
Molecular Formula
C11H14NO5P
Formula Weight
271.2
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
1 M sodium hydroxide: Soluble
SMILES
NC(C1=CC=C(P(O)(O)=O)C=C1)(C(O)=O)C2CC2
InChi Code
InChI=1S/C11H14NO5P/c12-11(10(13)14,7-1-2-7)8-3-5-9(6-4-8)18(15,16)17/h3-7H,1-2,12H2,(H,13,14)(H2,15,16,17)
InChi Key
IGODGTDUQSMDQU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $119

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    10 mg

    $215

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    25 mg

    $487

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    Product Description

    CPPG is an antagonist of group II and group III metabotropic glutamate receptors (mGluRs).1 It reverses inhibition of forskolin-induced cAMP accumulation induced by the mGluR group II selective agonist L-CCG-1 or the mGluR group III-selective agonist L-AP4 (Item No. 14538) in rat cerebrocortical slices (IC50s = 46.2 and 2.2 nM, respectively). Intrathecal administration of CPPG reduces formalin-induced flinching in a rat model of inflammatory pain.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Toms, N.J., Jane, D.E., Kemp, M.C., et al. The effects of (RS)-α-cyclopropyl-4-phosphonophenylglycine ((RS)-CPPG), a potent and selective metabotropic glutamate receptor antagonist. Br. J. Pharmacol. 119(5), 851-854 (1996).

    2. Okubo, M., Yamanaka, H., Kobayashi, K., et al. Differential expression of mGluRs in rat spinal dorsal horns and their modulatory effects on nocifensive behaviors. Mol. Pain 15, 1-13 (2019).