An inhibitor of glycoprotein processing and α-glucosidases
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N-Methyldeoxynojirimycin

Item No. 34378

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2R-(hydroxymethyl)-1-methyl-3R,4R,5S-piperidinetriol
CAS Number
69567-10-8
Synonyms
  • N-Methyl-1-Deoxynojirimycin
  • N-methyl DNJ
  • N-methyl dNM
  • N-Methylmoranoline
  • MOR 14
Molecular Formula
C7H15NO4
Formula Weight
177.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: slightly, sonicatedWater: slightly
SMILES
OC[C@@H]1[C@H]([C@@H]([C@H](CN1C)O)O)O
InChi Code
InChI=1S/C7H15NO4/c1-8-2-5(10)7(12)6(11)4(8)3-9/h4-7,9-12H,2-3H2,1H3/t4-,5+,6-,7-/m1/s1
InChi Key
AAKDPDFZMNYDLR-XZBKPIIZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $69

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    1 mg

    $120

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    5 mg

    $525

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    N-Methyldeoxynojirimycin is an inhibitor of α-glucosidases and glycoprotein processing.1 It inhibits the rabbit intestinal α-glucosidases sucrase and maltase (IC50s = 0.068 and 0.46 µg/ml, respectively) and R. niveus glucoamylase (IC50s = 1.6 and 4.7 µg/ml with starch or maltose as substrates, respectively).2 It is selective for these enzymes over β-glucosidase (IC50 = 363 µg/ml). N-Methyldeoxynojirimycin inhibits highly pathogenic avian influenza (HPAI) oligosaccharide processing in HPAI-infected chicken embryo cells.1 It reduces the cytopathic effect of HIV in infected Karpas-45 T cells.3 N-Methyldeoxynojirimycin also inhibits postprandial increases in blood glucose levels in sucrose-loaded rats (ED50 = 5.8 mg/kg).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Romero, P.A., Datema, R., and Schwarz, R.T. N-Methyl-1-deoxynojirimycin, a novel inhibitor of glycoprotein processing, and its effect on fowl plague virus maturation. Virology 130(1), 238-242 (1983).

    2. Yoshikuni, Y. Inhibition of intestinal α-glucosidase activity and postprandial hyperglycemia by moranoline and its N-alkyl derivatives. Agric. Biol. Chem. 52(1), 121-128 (1988).

    3. Karpas, A., Fleet, G.W.J., Dwek, R.A., et al. Aminosugar derivatives as potential anti-human immunodeficiency virus agents. Proc. Natl. Acad. Sci. USA 85(23), 9229-9233 (1988).