A quassinoid with diverse biological activities
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Quassin

Item No. 34382

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,12-dimethoxy-picrasa-2,12-diene-1,11,16-trione
CAS Number
76-78-8
Synonyms
  • NSC 36342
  • (+)-Quassin
Molecular Formula
C22H28O6
Formula Weight
388.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
257 nm
SMILES
C[C@]12[C@@]3([H])[C@@]4([C@@]([C@@H](C=C(C4=O)OC)C)([H])C[C@@]1([H])OC(C[C@@]2([H])C(C)=C(C3=O)OC)=O)C
InChi Code
InChI=1S/C22H28O6/c1-10-7-14(26-5)20(25)22(4)12(10)8-15-21(3)13(9-16(23)28-15)11(2)18(27-6)17(24)19(21)22/h7,10,12-13,15,19H,8-9H2,1-6H3/t10-,12+,13+,15-,19+,21-,22+/m1/s1
InChi Key
IOSXSVZRTUWBHC-LBTVDEKVSA-N
Origin
Plant/Quassia amara
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Quassin is a quassinoid that has been found in Q. amara and has diverse biological activities.1,2,3 It is active against chloroquine-sensitive and -resistant strains of P. falciparum (IC50 = 0.15 µM for both).1 Quassin has antifeedant and insecticidal activity against the diamondback moth (P. xylostella) when applied to dietary cabbage leaf discs at 16, 31.9, or 63.7 µg/cm2.2 It increases viability of SH-SY5Y cells in a model of hydrogen peroxide-induced neuronal injury when used at concentrations of 25, 50, or 100 µM.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mishra, K., Chakraborty, D., Pal, A., et al. Plasmodium falciparum: in vitro interaction of quassin and neo-quassin with artesunate, a hemisuccinate derivative of artemisinin. Exp. Parasitol. 124(4), 421-427 (2010).

    2. Daido, M., Fukamiya, N., Okano, M., et al. Antifeedant and insecticidal activity of quassinoids against diamondback moth (Plutella xylostella). Biosci. Biotechnol. Biochem. 57(2), 2440246 (1993).

    3. He, C., Wang, Y., Yang, T., et al. Quassinoids with insecticidal activity against Diaphorina citri Kuwayama and neuroprotective activities from Picrasma quassioides. J. Agric. Food. Chem. 68(1), 117-127 (2020).