A diterpenoid with antiandrogenic activity
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Triptophenolide

Item No. 34390

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3bR,9bS)-3b,4,5,9b,10,11-hexahydro-6-hydroxy-9b-methyl-7-(1-methylethyl)-phenanthro[1,2-c]furan-1(3H)-one
CAS Number
74285-86-2
Synonyms
  • Hypolide
  • (+)-Triptophenolide
Molecular Formula
C20H24O3
Formula Weight
312.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
SMILES
C[C@@]12[C@](CCC3=C(O)C(C(C)C)=CC=C32)([H])C4=C(C(OC4)=O)CC1
InChi Code
InChI=1S/C20H24O3/c1-11(2)12-4-6-16-14(18(12)21)5-7-17-15-10-23-19(22)13(15)8-9-20(16,17)3/h4,6,11,17,21H,5,7-10H2,1-3H3/t17-,20+/m0/s1
InChi Key
KPXIBWGPZSPABK-FXAWDEMLSA-N
Origin
Plant/Salvia japonica
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    25 mg

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    Product Description

    Triptophenolide is a diterpenoid that has been found in T. wilfordii and has antiandrogenic activity.1 It is an antagonist of wild-type and mutant androgen receptors (ARs; IC50s = 260, 388, 480, and 437 nM for wild-type, ART877A, ARF876L, and ARW741C/T877A, respectively, in transactivation assays). Triptophenolide (5 µM) inhibits the growth of, and reduces AR levels in, LNCaP prostate cancer cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. He, Y., Wu, M., Liu, Y., et al. Identification of triptophenolide from Tripterygium wilfordii as a pan-antagonist of androgen receptor. ACS Med. Chem. Lett. 7(12), 1024-1027 (2016).