A metabolite of trazodone
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4’-hydroxy Trazodone

Item No. 34409

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[3-[4-(3-chloro-4-hydroxyphenyl)-1-piperazinyl]propyl]-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one
CAS Number
53818-10-3
Molecular Formula
C19H22ClN5O2
Formula Weight
387.9
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: slightly solubleMethanol: slightly, sonicated
SMILES
O=C1N2C=CC=CC2=NN1CCCN3CCN(CC3)C4=CC=C(C(Cl)=C4)O
InChi Code
InChI=1S/C19H22ClN5O2/c20-16-14-15(5-6-17(16)26)23-12-10-22(11-13-23)7-3-9-25-19(27)24-8-2-1-4-18(24)21-25/h1-2,4-6,8,14,26H,3,7,9-13H2
InChi Key
FNUZSRSXQFIOPL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $321

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    Product Description

    4’-hydroxy Trazodone is a metabolite of the antidepressant and sedative trazodone.1 It is an inhibitor of organic anion transporter 3 (OAT3; Ki = 16.9 µM) and is selective for OAT3 over OAT1 (Ki = >200 µM).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yamato, C., Takahashi, T., Fujita, T., et al. Studies on metabolism of trazodone, II. Metabolic fate after intravenous administration and effects on liver microsomal drug-metabolizing enzymes in rats. Xenobiotica 4(12), 765-777 (1974).

    2. Zou, L., Matsson, P., Stecula, A., et al. Drug metabolites potently inhibit renal organic anion transporters, OAT1 and OAT3. J. Pharm. Sci. 110(1), 347-353 (2021).