An LXR agonist
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AZ876

Item No. 34413

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(1,1-dimethylethyl)-5-phenyl-4-[[4-(1-piperidinyl)phenyl]amino]-3(2H)-isothiazolone, 1,1-dioxide
CAS Number
898800-26-5
Molecular Formula
C24H29N3O3S
Formula Weight
439.6
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 1 mg/ml
λmax
254 nm
SMILES
O=C(C(NC1=CC=C(N2CCCCC2)C=C1)=C3C4=CC=CC=C4)N(C(C)(C)C)S3(=O)=O
InChi Code
InChI=1S/C24H29N3O3S/c1-24(2,3)27-23(28)21(22(31(27,29)30)18-10-6-4-7-11-18)25-19-12-14-20(15-13-19)26-16-8-5-9-17-26/h4,6-7,10-15,25H,5,8-9,16-17H2,1-3H3
InChi Key
IVANYIPLGFVBGR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $52

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    10 mg

    $93

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    25 mg

    $189

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    50 mg

    $325

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    AZ876 is a liver X receptor (LXR) agonist.1,2 It activates LXRα and LXRβ in a transactivation assay in U2OS osteosarcoma cells (EC50 = 6 and 73 nM, respectively).1 AZ876 reduces phenylephrine-induced increases in cell size and protein synthesis in isolated neonatal rat ventricular myocytes.2 It decreases plasma cholesterol and VLDL levels and increases plasma triglyceride and HDL levels, as well as decreases the number and size of aortic root lesions in mice fed a Western diet in an APOE*3-Leiden transgenic mouse model of atherosclerosis when administered at a dose of 20 µmol/kg.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. van der Hoorn, J.W.A., Lindén, D., Lindahl, U., et al. Low dose of the liver X receptor agonist, AZ876, reduces atherosclerosis in APOE*3Leiden mice without affecting liver or plasma triglyceride levels. Br. J. Pharmacol. 162(7), 1553-1563 (2011).

    2. Cannon, M.V., Yu, H., Candido, W.M., et al. The liver X receptor agonist AZ876 protects against pathological cardiac hypertrophy and fibrosis without lipogenic side effects. Eur. J. Heart Fail. 17(3), 273-282 (2015).