A SIRT1 activator
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SRT 3025 (hydrochloride)

Item No. 34420

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(3-methoxypropyl)-2-phenyl-N-[2-[6-(1-pyrrolidinylmethyl)thiazolo[5,4-b]pyridin-2-yl]phenyl]-4-thiazolecarboxamide, monohydrochloride
CAS Number
2070015-26-6
Molecular Formula
C31H31N5O2S2 • HCl
Formula Weight
606.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: 30 mg/mlDMF: slightly solubleDMSO: slightly solubleEthanol: slightly soluble
λmax
231, 281, 353 nm
SMILES
O=C(C1=C(CCCOC)SC(C2=CC=CC=C2)=N1)NC3=C(C4=NC5=CC(CN6CCCC6)=CN=C5S4)C=CC=C3.Cl
InChi Code
InChI=1S/C31H31N5O2S2.ClH/c1-38-17-9-14-26-27(35-29(39-26)22-10-3-2-4-11-22)28(37)33-24-13-6-5-12-23(24)30-34-25-18-21(19-32-31(25)40-30)20-36-15-7-8-16-36;/h2-6,10-13,18-19H,7-9,14-17,20H2,1H3,(H,33,37);1H
InChi Key
LGRBDTOIPNDWMN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $69

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    50 mg

    $263

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    100 mg

    $493

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    250 mg

    $983

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    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    SRT 3025 is an activator of sirtuin 1 (SIRT1).1,2,3 It increases SIRT1 levels in, and inhibits RANKL-induced osteoclastogenesis of, mouse bone marrow-derived macrophages (BMDMs) when used at a concentration of 2 µM.1 SRT 3025 inhibits the proliferation of SU.86.86 pancreatic adenocarcinoma cells (IC50 = 0.98 µM).2 It decreases plasma levels of LDL, VLDL, and total cholesterol in ApoE-/- mice fed a high-cholesterol diet when administered at a dose of 3.18 g/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gurt, I., Artsi, H., Cohen-Kfir, E., et al. The Sirt1 activators SRT2183 and SRT3025 Inhibit RANKL-induced osteoclastogenesis in bone marrow-derived macrophages and down-regulate Sirt3 in Sirt1 null cells. PLoS One 10(7), e0134391 (2015).

    2. Chini, C.C.S., Espindola-Netto, J.M., Mondal, G., et al. SIRT1-activating compounds (STAC) negatively regulate pancreatic cancer cell growth and viability through a SIRT1 lysosomal-dependent pathway. Clin. Cancer Res. 22(10), 2496-2507 (2015).

    3. Miranda, M.X., van Tits, L.J., Lohmann, C., et al. The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression. Eur. Heart J. 36(1), 51-59 (2015).