A VEGFR2 inhibitor
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SKLB1002

Item No. 34422

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6,7-dimethoxy-4-[(5-methyl-1,3,4-thiadiazol-2-yl)thio]-quinazoline
CAS Number
1225451-84-2
Molecular Formula
C13H12N4O2S2
Formula Weight
320.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: 30 mg/ml
λmax
245, 249, 276, 342 nm
SMILES
COC1=CC2=C(N=CN=C2SC3=NN=C(C)S3)C=C1OC
InChi Code
InChI=1S/C13H12N4O2S2/c1-7-16-17-13(20-7)21-12-8-4-10(18-2)11(19-3)5-9(8)14-6-15-12/h4-6H,1-3H3
InChi Key
RQVGFDBMONQTBC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $54

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    10 mg

    $75

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    25 mg

    $120

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    Product Description

    SKLB1002 is a VEGFR2 inhibitor (IC50 = 32 nM).1 It is selective for VEGFR2 over a panel of 16 additional kinases (IC50s = 619->10,000 nM). SKLB1002 inhibits tube formation, migration, and VEGF-induced proliferation of human umbilical vein endothelial cells (HUVECs). It induces tumor cell apoptosis, decreases tumor microvessel density, and reduces tumor growth in an SW620 mouse xenograft model when administered at a dose of 50 or 100 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, S., Cao, Z., Tian, H., et al. SKLB1002, a novel potent inhibitor of VEGF receptor 2 signaling, inhibits angiogenesis and tumor growth in vivo. Clin. Cancer Res. 17(13), 4439-4450 (2011).