A phenol with diverse biological activities
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Orcinol

Item No. 34467

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-methyl-1,3-benzenediol
CAS Number
504-15-4
Synonyms
  • 3,5-Dihydroxytoluene
  • 5-Methylresorcinol
  • NSC 12441
Molecular Formula
C7H8O2
Formula Weight
124.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
OC1=CC(C)=CC(O)=C1
InChi Code
InChI=1S/C7H8O2/c1-5-2-6(8)4-7(9)3-5/h2-4,8-9H,1H3
InChi Key
OIPPWFOQEKKFEE-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 g

    $75

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    25 g

    $130

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    50 g

    $241

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    100 g

    $333

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    Product Description

    Orcinol is a polyketide synthase-derived phenol that has been found in F. graminearum and has diverse biological activities.1,2,3 It scavenges DPPH (Item No. 14805) radicals (IC50 = 2.93 mM).2 Orcinol (2.5 and 5 mg/kg) increases the number of entries into and percentage of time spent in the open arms of the elevated plus maze in mice, indicating anxiolytic-like activity.3 It has also been used in the colorimetric detection of carbohydrates.4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jørgensen, S.H., Frandsen, R.J.N., Nielsen, K.F., et al. Fusarium graminearum PKS14 is involved in orsellinic acid and orcinol synthesis. Fungal Genet. Biol. 70, 24-31 (2014).

    2. Lopes, T.I.B., Coelho, R.H., Toshida, N.C., et al. Radical-scavenging activity of orsellinates. Chem. Pharm. Bull. (Tokyo) 56(11), 1551-1554 (2008).

    3. Wang, X., Li, G., Li, P., et al. Anxiolytic effects of orcinol glucoside and orcinol monohydrate in mice. Pharm. Biol. 53(6), 876-881 (2015).

    4. DeGrandis, S., Law, H., Brunton, J., et al. Globotetraosylceramide is recognized by the pig edema disease toxin. The Journal of Biological Chemisty 264(21), 12520-12525 (1989).

    5. Bruckner, J. Estimation of monosaccharides by the orcinol-sulphuric acid reaction. Biochem. J. 60(2), 200-205 (1955).