A 5-HT6 receptor antagonist
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Ro 04-6790 (hydrochloride hydrate)

Item No. 34476

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]-benzenesulfonamide, dihydrochloride hydrate
Molecular Formula
C12H16N6O2S • 2HCl [XH2O]
Formula Weight
381.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 15 mg/mlWater: 5 mg/ml
SMILES
O=S(NC1=NC(NC)=NC(NC)=C1)(C2=CC=C(C=C2)N)=O.Cl.Cl.O
InChi Code
InChI=1S/C12H16N6O2S.2ClH.H2O/c1-14-10-7-11(17-12(15-2)16-10)18-21(19,20)9-5-3-8(13)4-6-9;;;/h3-7H,13H2,1-2H3,(H3,14,15,16,17,18);2*1H;1H2
InChi Key
NAXNKMHJJJLURY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $121

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    10 mg

    $182

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    25 mg

    $713

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    Product Description

    Ro 04-6790 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT6 (Ki = 44.7 nM).1 It is selective for 5-HT6 receptors over a panel of 23 additional receptors at 10 µM. Ro 04-6790 inhibits 5-HT-induced cAMP production in HeLa cells expressing human 5-HT6 (pA2 = 6.75). In vivo, Ro 04-6790 (10 and 30 mg/kg) induces stretching and yawning behavior in rats. It reverses scopolamine-induced decreases in novel object discrimination in rats.2 Ro 04-6790 (3, 10, and 30 mg/kg) also attenuates cue-induced cocaine-seeking behavior in rats.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sleight, A.J., Boess, F.G., Bös, M., et al. Characterization of Ro 04-6790 and Ro 63-0563: Potent and selective antagonists at human and rat 5-HT6 receptors. Br. J. Pharmacol. 124(3), 556-562 (1998).

    2. Woolley, M.L., Marsden, C.A., Sleight, A.J., et al. Reversal of a cholinergic-induced deficit in a rodent model of recognition memory by the selective 5-HT6 receptor antagonist, Ro 04-6790. Psychopharmacology (Berl) 170(4), 358-367 (2003).