A 5-HT6 receptor antagonist
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Ro 04-6790 (hydrochloride hydrate)

Item No. 34476

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]-benzenesulfonamide, dihydrochloride hydrate
Molecular Formula
C12H16N6O2S • 2HCl [XH2O]
Formula Weight
381.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 15 mg/mlWater: 5 mg/ml
SMILES
O=S(NC1=NC(NC)=NC(NC)=C1)(C2=CC=C(C=C2)N)=O.Cl.Cl.O
InChi Code
InChI=1S/C12H16N6O2S.2ClH.H2O/c1-14-10-7-11(17-12(15-2)16-10)18-21(19,20)9-5-3-8(13)4-6-9;;;/h3-7H,13H2,1-2H3,(H3,14,15,16,17,18);2*1H;1H2
InChi Key
NAXNKMHJJJLURY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $121

    Add

    10 mg

    $182

    Add

    25 mg

    $713

    Add
    Product Description

    Ro 04-6790 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT6 (Ki = 44.7 nM).1 It is selective for 5-HT6 receptors over a panel of 23 additional receptors at 10 µM. Ro 04-6790 inhibits 5-HT-induced cAMP production in HeLa cells expressing human 5-HT6 (pA2 = 6.75). In vivo, Ro 04-6790 (10 and 30 mg/kg) induces stretching and yawning behavior in rats. It reverses scopolamine-induced decreases in novel object discrimination in rats.2 Ro 04-6790 (3, 10, and 30 mg/kg) also attenuates cue-induced cocaine-seeking behavior in rats.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sleight, A.J., Boess, F.G., Bös, M., et al. Characterization of Ro 04-6790 and Ro 63-0563: Potent and selective antagonists at human and rat 5-HT6 receptors. Br. J. Pharmacol. 124(3), 556-562 (1998).

    2. Woolley, M.L., Marsden, C.A., Sleight, A.J., et al. Reversal of a cholinergic-induced deficit in a rodent model of recognition memory by the selective 5-HT6 receptor antagonist, Ro 04-6790. Psychopharmacology (Berl) 170(4), 358-367 (2003).