An NPBWR1 antagonist
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CYM 50769

Item No. 34484

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-chloro-2-(9H-fluoren-9-yl)-4-(4-methoxyphenoxy)-3(2H)-pyridazinone
CAS Number
1421365-63-0
Molecular Formula
C24H17ClN2O3
Formula Weight
416.9
Purity
≥98%
Formulation (Request formulation change)
A solid
λmax
269 nm
SMILES
O=C1C(OC2=CC=C(C=C2)OC)=C(C=NN1C3C4=C(C5=C3C=CC=C5)C=CC=C4)Cl
InChi Code
InChI=1S/C24H17ClN2O3/c1-29-15-10-12-16(13-11-15)30-23-21(25)14-26-27(24(23)28)22-19-8-4-2-6-17(19)18-7-3-5-9-20(18)22/h2-14,22H,1H3
InChi Key
QHVSQUYCVUHYKT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $167

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    10 mg

    $255

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    25 mg

    $583

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    Product Description

    CYM 50769 is a nonpeptide antagonist of neuropeptides B and W receptor 1 (NPBWR1).1 It inhibits neuropeptide W-induced activation of NPBWR1 (IC50 = 0.12 µM). CYM 50769 is selective for NPBWR1 over a panel of 30 G protein-coupled receptors (GPCRs), enzymes, transporters, and ion channels at 30 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Guerrero, M., Urbano, M., Schaeffer, M.-T., et al. SAR analysis of novel non-peptidic NPBWR1 (GPR7) antagonists. Bioorg. Med. Chem. Lett. 23(3), 614-619 (2013).