A Met kinase inhibitor
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NVP-BVU972

Item No. 34495

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-[[6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl]-quinoline
CAS Number
1185763-69-2
Molecular Formula
C20H16N6
Formula Weight
340.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
231, 254 nm
SMILES
CN(N=C1)C=C1C2=NN3C(C=C2)=NC=C3CC4=CC(C=CC=N5)=C5C=C4
InChi Code
InChI=1S/C20H16N6/c1-25-13-16(11-23-25)19-6-7-20-22-12-17(26(20)24-19)10-14-4-5-18-15(9-14)3-2-8-21-18/h2-9,11-13H,10H2,1H3
InChi Key
RNCNPRCUHHDYPC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $63

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    5 mg

    $168

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    10 mg

    $303

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    Product Description

    NVP-BVU972 is an inhibitor of Met kinase (IC50 = 14 nM).1 It is selective for Met over a panel of 62 additional kinases (IC50s = >1 µM for all). It inhibits proliferation of Met-amplified GTL-16 gastric, MKN45 gastric, and EBC-1 lung cancer cells (IC50s = 66, 32, and 82 nM, respectively). NVP-BVU972 inhibits Met autophosphorylation in GTL-16 cells and Met phosphorylation induced by hepatocyte growth factor (HGF) in A549 cells (IC50s = 7.3 and 22 nM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tiedt, R., Degenkolbe, E., Furet, P., et al. A drug resistance screen using a selective MET inhibitor reveals a spectrum of mutations that partially overlap with activating mutations found in cancer patients. Cancer Res. 71(15), 5255-5264 (2011).