A metabolite of dolutegravir
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Parent Compound(s)
22191Dolutegravir
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Dolutegravir M1

Item No. 34508

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,4R,6,8,12,12aS-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-2H-pyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
CAS Number
1485081-26-2
Molecular Formula
C13H15N3O5
Formula Weight
293.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: slightly soluble
λmax
257, 323 nm
SMILES
O=C1C(N(C=C2C(N)=O)C[C@@]3([H])N1[C@@H](CCO3)C)=C(O)C2=O
InChi Code
InChI=1S/C13H15N3O5/c1-6-2-3-21-8-5-15-4-7(12(14)19)10(17)11(18)9(15)13(20)16(6)8/h4,6,8,18H,2-3,5H2,1H3,(H2,14,19)/t6-,8+/m1/s1
InChi Key
IORBWJQXSCJOCL-SVRRBLITSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    Cayman Chemical
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    Product Description

    Dolutegravir M1 is a metabolite of the HIV integrase inhibitor dolutegravir (Item No. 22191).1 It is formed primarily by the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1B1.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhu, J., Wang, P., Li, F., et al. CYP1A1 and 1B1-mediated metabolic pathways of dolutegravir, an HIV integrase inhibitor. Biochem. Pharmacol. 158, 174-184 (2018).