A muscarinic acetylcholine receptor antagonist
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Benzetimide (hydrochloride)

Item No. 34527

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-phenyl-1′-(phenylmethyl)-[3,4′-bipiperidine]-2,6-dione, monohydrochloride
CAS Number
5633-14-7
Synonyms
  • Dioxatrine
  • R 4929
  • Spasmentral
Molecular Formula
C23H26N2O2 • HCl
Formula Weight
398.9
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: slightly soluble, sonicatedWater: slightly soluble
SMILES
O=C(N1)CCC(C2CCN(CC3=CC=CC=C3)CC2)(C4=CC=CC=C4)C1=O.Cl
InChi Code
InChI=1S/C23H26N2O2.ClH/c26-21-11-14-23(22(27)24-21,19-9-5-2-6-10-19)20-12-15-25(16-13-20)17-18-7-3-1-4-8-18;/h1-10,20H,11-17H2,(H,24,26,27);1H
InChi Key
XSOOSXRNMDUWEM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $41

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    25 mg

    $95

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    50 mg

    $149

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    100 mg

    $198

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    Product Description

    Benzetimide is a muscarinic acetylcholine receptor (mAChR) antagonist.1 It induces mydriasis and inhibits pilocarpine-induced salivation and lacrimation in rats (ED50s = 0.06 and 0.04 mg/kg, respectively).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gray, J.A., Lüllmann, H., Mitchelson, F.J., et al. Stereoselective binding in cardiac tissue of the enatiomers of benzetimide, and antimuscarinic drug. Br. J. Pharmacol. 56(4), 485-490 (1976).

    2. Janssen, P.A.J., and Niemegeers, C.J.E. The peripheral and central anticholinergic properties of benzetimide (R 4929) and other atropine-like drugs as measured in a new anti-pilocarpine test in rats. Psychopharmacologia 11(3), 231-254 (1967).