An AChE inhibitor
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Ipidacrine

Item No. 34529

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinolin-9-amine
CAS Number
62732-44-9
Synonyms
  • NIK-247
Molecular Formula
C12H16N2
Formula Weight
188.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlDMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
λmax
215, 251 nm
SMILES
NC1=C(CCC2)C2=NC3=C1CCCC3
InChi Code
InChI=1S/C12H16N2/c13-12-8-4-1-2-6-10(8)14-11-7-3-5-9(11)12/h1-7H2,(H2,13,14)
InChi Key
YLUSMKAJIQOXPV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $69

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    1 g

    $115

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    5 g

    $525

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    Product Description

    Ipidacrine is an inhibitor of acetylcholinesterase (AChE; IC50 = 270 nM).1 It induces long-term potentiation (LTP) in rat hippocampal slices, an effect that can be blocked by the muscarinic antagonists atropine (Item No. 12008) or pirenzepine (Item No. 29527), when used at a concentration of 10 µM.2 Ipidacrine (0.03-1 mg/kg) prevents memory deficits induced by the anticholinergic agent scopolamine in the passive avoidance test in rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ogura, H., Kosasa, T., Kuriya, Y., et al. Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Methods Find. Exp. Clin. Pharmacol. 22(8), 609-613 (2000).

    2. Yoshida, S., and Suzuki, N. Antiamnesic and cholinomimetic side-effects of the cholinesterase inhibitors, physostigmine, tacrine and NIK-247 in rats. Eur. J. Pharmacol. 250(1), 117-124 (1993).