A peptide FPR2 antagonist
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PBP 10 (trifluoroacetate salt)

Item No. 34535

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N2-[2-[3,6-bis(diethylamino)xanthylium-9-yl]benzoyl]-L-glutaminyl-L-arginyl-L-leucyl-L-phenylalanyl-L-glutaminyl-L-valyl-L-lysylglycyl-L-arginine, trifluoroacetate salt
Synonyms
  • RhB-QRLFQVKGRR-OH
Molecular Formula
C84H127N24O15 • XCF3COOH
Formula Weight
1713.1
Purity
≥90%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 5 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
557 nm
SMILES
CCN(C1=CC([O+]=C2C=C(C=CC2=C3C4=C(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC5=CC=CC=C5)C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)CCCNC(N)=N)=O)=O)CCCCN)=O)C(C)C)=O)CCC(N)=O)=O)=O)CC(C)C)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)C=CC=C4)N(CC)CC)=C3C=C1)CC.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C84H126N24O15.C2HF3O2/c1-9-107(10-2)51-31-33-55-65(45-51)123-66-46-52(108(11-3)12-4)32-34-56(66)70(55)53-25-16-17-26-54(53)72(112)99-60(35-37-67(86)109)76(116)100-59(29-21-41-95-83(90)91)75(115)104-63(43-48(5)6)78(118)105-64(44-50-23-14-13-15-24-50)79(119)101-61(36-38-68(87)110)77(117)106-71(49(7)8)80(120)102-57(27-18-19-39-85)73(113)97-47-69(111)98-58(28-20-40-94-82(88)89)74(114)103-62(81(121)122)30-22-42-96-84(92)93;3-2(4,5)1(6)7/h13-17,23-26,31-34,45-46,48-49,57-64,71H,9-12,18-22,27-30,35-44,47,85H2,1-8H3,(H26-,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100,101,102,103,104,105,106,109,110,111,112,113,114,115,116,117,118,119,120,121,122);(H,6,7)/p+1/t57-,58-,59-,60-,61-,62-,63-,64-,71-;/m0./s1
InChi Key
NDZBKRCQEVIYAM-XADHZNKISA-O
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    PBP 10 is a peptide formyl peptide receptor 2 (FPR2) antagonist (IC50 = 60 nM).1 It is active against E. coli, P. aeruginosa, and S. pneumoniae when used at concentrations ranging from 0.1 to 100 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Skovbakke, S.L., Holdfeldt, A., Nielsen, C., et al. Combining elements from two antagonists of formyl peptide receptor 2 generates more potent peptidomimetic antagonists. J. Med. Chem. 60(16), 6991-6997 (2017).

    2. Bucki, R., Pastore, J.J., Randhawa, P., et al. Antibacterial activities of rhodamine B-conjugated gelsolin-derived peptides compared to those of the antimicrobial peptides cathelicidin LL37, magainin II, and melittin. Antimicrob. Agents Chemother. 48(5), 1526-1533 (2004).