A DNA-crosslinking agent
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cDPCP

Item No. 34547

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(SP-4-3)-diamminechloro(pyridine)-platinum(1+), monochloride
CAS Number
106343-59-3
Molecular Formula
C5H11ClN3Pt • Cl
Formula Weight
379.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly solubleWater: Slightly soluble
SMILES
[Cl-][Pt+2]([NH3])([N]1=CC=CC=C1)[NH3].[Cl-]
InChi Code
InChI=1S/C5H5N.2ClH.2H3N.Pt/c1-2-4-6-5-3-1;;;;;/h1-5H;2*1H;2*1H3;/q;;;;;+2/p-2
InChi Key
JDWBOMGRVMIMAU-UHFFFAOYSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

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    1 mg

    $134

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    5 mg

    $530

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    Cayman Chemical
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    Product Description

    cDPCP is a platinum-containing DNA-crosslinking agent.1 Unlike cisplatin (Item No. 13119) or oxaliplatin (Item No. 13106), cDPCP forms monofunctional DNA adducts. It is transported into cells by organic cation transporter 1 (OCT1) and OCT2, inhibiting proliferation of MDCK cells expressing the human transporters with IC50 values of 8.1 and 1.5 µM, respectively. cDPCP inhibits RNA polymerase II-mediated transcription in a reporter assay using HeLa cells. It increases survival in murine S180 sarcoma and P388 leukemia models when administered at doses of 40 and 80 mg/kg, respectively.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lovejoy, K.S., Todd, R.C., Zhang, S., et al. cis-Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects. Proc. Natl. Acad. Sci. USA 105(26), 8902-9807 (2008).

    2. Hollis, L.S., Amundsen, A.R., and Stern, E.W. Chemical and biological properties of a new series of cis-diammineplatinum(II) antitumor agents containing three nitrogen donors: cis-[Pt(NH3)2(N-donor)Cl]+. J. Med. Chem. 32, 128-136 (1989).