A histamine H4 receptor antagonist
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

A-943931 (hydrochloride hydrate)

Item No. 34554

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(3R)-3-amino-1-pyrrolidinyl]-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidin-2-amine, dihydrochloride, hydrate
Molecular Formula
C17H21N5 • 2HCl [XH2O]
Formula Weight
368.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Water: 100 mM
SMILES
NC1=NC(N2CC[C@H](C2)N)=C(CCCC3=CC=CC=C34)C4=N1.O.Cl.Cl
InChi Code
InChI=1S/C17H21N5.2ClH.H2O/c18-12-8-9-22(10-12)16-14-7-3-5-11-4-1-2-6-13(11)15(14)20-17(19)21-16;;;/h1-2,4,6,12H,3,5,7-10,18H2,(H2,19,20,21);2*1H;1H2/t12-;;;/m1.../s1
InChi Key
FIZFLIYBVYYMAI-CSIATVMVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $36

    Add

    5 mg

    $153

    Add

    10 mg

    $268

    Add

    25 mg

    $587

    Add
    Product Description

    A-943931 is a histamine H4 receptor antagonist (Ki = 3.8 nM).1 In vivo, A-943931 inhibits scratching induced by clobenpropit (Item No. 10011126) in mice (ED50 = 26 µmoles/kg, i.p.).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Milicic, I., Witte, D.G., Miller, T.L., et al. Identification of two potent and selective histamine H4 receptor antagonists with antipruritic activity. The FASEB Journal 23(S1), 760.768-760.768 (2009).