A hydroxy fatty acid
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12-hydroxy Stearic Acid

Item No. 34558

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
12-hydroxy-octadecanoic acid
CAS Number
106-14-9
Synonyms
  • 12-HSA
  • NSC 2385
Molecular Formula
C18H36O3
Formula Weight
300.5
Purity
≥85%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 10 mg/ml
SMILES
CCCCCCC(O)CCCCCCCCCCC(O)=O
InChi Code
InChI=1S/C18H36O3/c1-2-3-4-11-14-17(19)15-12-9-7-5-6-8-10-13-16-18(20)21/h17,19H,2-16H2,1H3,(H,20,21)
InChi Key
ULQISTXYYBZJSJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $36

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    5 g

    $80

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    10 g

    $140

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    Cayman Chemical
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    Product Description

    12-hydroxy Stearic acid is a hydroxy fatty acid produced by the hydrogenation of ricinoleic acid (Item No. 10009369).1 It is a low molecular weight gelator that self-assembles to form organogels.2 Administration of paclitaxel (Item No. 10461) in 12-hydroxy stearic acid-containing gel nanocarriers enhances tumor growth suppression in an H22 murine hepatocellular carcinoma model.3 Formulations containing 12-hydroxy stearic acid have been used in cosmetic products as emollients.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fameau, A.-L., and Rogers, M.A. The curious case of 12-hydroxystearic acid — the Dr. Jekyll & Mr. Hyde of molecular gelators. Curr. Opin. Colloid Interface Sci. 45, 68-82 (2020).

    2. Burkhardt, M., Noirez, L., and Gradzielski, M. Organogels based on 12-hydroxy stearic acid as a leitmotif: Dependence of gelation properties on chemical modifications. J. Colloid Interface Sci. 466, 369-376 (2016).

    3. He, W., Lv, Y., Zhao, Y., et al. Core-shell structured gel-nanocarriers for sustained drug release and enhanced antitumor effect. Int. J. Pharm. 484(1-2), 163-171 (2015).