A glycolipid TLR4 antagonist
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IAXO-102

Item No. 34567

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
methyl 6-amino-6-deoxy-2,3-di-O-tetradecyl-α-D-glucopyranoside
CAS Number
1115270-63-7
Molecular Formula
C35H71NO5
Formula Weight
585.9
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Soluble
SMILES
CCCCCCCCCCCCCCO[C@@H]1[C@H]([C@@H]([C@H](O[C@@H]1OC)CN)O)OCCCCCCCCCCCCCC
InChi Code
InChI=1S/C35H71NO5/c1-4-6-8-10-12-14-16-18-20-22-24-26-28-39-33-32(37)31(30-36)41-35(38-3)34(33)40-29-27-25-23-21-19-17-15-13-11-9-7-5-2/h31-35,37H,4-30,36H2,1-3H3/t31-,32-,33+,34-,35+/m1/s1
InChi Key
DJVFNDPRLMVKKO-KJQSSVQNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $81

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    5 mg

    $357

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    10 mg

    $633

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    Product Description

    IAXO-102 is a glycolipid and an antagonist of toll-like receptor 4 (TLR4).1 It inhibits lipid A-induced TLR4 activation in a cell-based assay (IC50 = 5.013 µM). IAXO-102 (10 mg/kg) reduces LPS-induced lethality in mice. It decreases angiotensin II-induced aortic expansion and rupture, as well as the incidence of abdominal aortic aneurysms, in ApoE-/- mice when administered at a dose of 3 mg/kg.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Piazza, M., Rossini, C., Fiorentina, S.D., et al. Glycolipids and benzylammonium lipids as novel antisepsis agents: Synthesis and biological characterization. J. Med. Chem. 52(4), 1209-1213 (2009).

    2. Huggins, C., Pearce, S.F., Peri, F., et al. A novel small molecule TLR4 antagonist (IAXO-102) negatively regulates non-hematopoietic toll like receptor 4 signalling and inhibits aortic aneurysms development. Atherosclerosis 242(2), 5630570 (2015).