An inhibitor of p38α MAPK
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AMG 548

Item No. 34577

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[(2S)-2-amino-3-phenylpropyl]amino]-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-4(3H)-pyrimidinone
CAS Number
864249-60-5
Molecular Formula
C29H27N5O
Formula Weight
461.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:4): 0.20 mg/ml
λmax
222 nm
SMILES
O=C1C(C2=CC3=C(C=CC=C3)C=C2)=C(C4=CC=NC=C4)N=C(N1C)NC[C@@H](N)CC5=CC=CC=C5
InChi Code
InChI=1S/C29H27N5O/c1-34-28(35)26(24-12-11-21-9-5-6-10-23(21)18-24)27(22-13-15-31-16-14-22)33-29(34)32-19-25(30)17-20-7-3-2-4-8-20/h2-16,18,25H,17,19,30H2,1H3,(H,32,33)/t25-/m0/s1
InChi Key
RQVKVJIRFKVPBF-VWLOTQADSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $44

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    25 mg

    $105

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    50 mg

    $198

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    100 mg

    $374

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    Product Description

    AMG 548 is an inhibitor of p38α MAPK (Ki = 0.5 nM).1 It is selective for p38α over p38γ, p38δ, JNK1, JNK2, and JNK3 (Kis = 2,600, 4,100, 11,480, 39, and 61 nM, respectively) and is greater than 1,000-fold selective over a panel of 36 additional kinases but also inhibits p38β (Ki = 3.6 nM). AMG 548 inhibits LPS-induced production of TNF-α and IL-1β in isolated human whole blood (IC50s = 3 and 7 nM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lee, M.R., and Dominguez, C. MAP kinase p38 inhibitors: Clinical results and an intimate look at their interactions with p38α protein. Curr. Med. Chem. 12(25), 2979-2994 (2005).