An inverse agonist of GHS-R1a
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AZ-GHS-22

Item No. 34611

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-chloro-N-[[[6-[[3-(4-methyl-1-piperazinyl)propyl]sulfonyl]-2-benzothiazolyl]amino]carbonyl]-5-(4-morpholinyl)-benzamide
CAS Number
1143020-91-0
Molecular Formula
C27H33ClN6O5S2
Formula Weight
621.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
0.1 M HCl: 25 mg/mlDMSO: 50 mg/ml
SMILES
O=C(NC1=NC2=C(S1)C=C(S(=O)(CCCN3CCN(CC3)C)=O)C=C2)NC(C4=CC(N5CCOCC5)=CC=C4Cl)=O
InChi Code
InChI=1S/C27H33ClN6O5S2/c1-32-8-10-33(11-9-32)7-2-16-41(37,38)20-4-6-23-24(18-20)40-27(29-23)31-26(36)30-25(35)21-17-19(3-5-22(21)28)34-12-14-39-15-13-34/h3-6,17-18H,2,7-16H2,1H3,(H2,29,30,31,35,36)
InChi Key
XWFQFKFKWKWIEW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $81

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    5 mg

    $357

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    10 mg

    $633

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    Product Description

    AZ-GHS-22 is an inverse agonist of the growth hormone secretagogue receptor 1a (GHS-R1a), which is also known as the ghrelin receptor.1 It binds to GHS-R1a with an IC50 value of 0.77 nM. AZ-GHS-22 decreases food intake in mice by 54% in the first two hours after administration of a 100 mg/kg dose.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. McCoull, W., Barton, P., Brown, A.J.H., et al. Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonists. J. Med. Chem. 57(14), 6128-6140 (2014).