An alkaloid and a toxin
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Deltaline

Item No. 34612

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1α,6β,14α,16β)-20-ethyl-1,14,16-trimethoxy-4-methyl-7,8-[methylenebis(oxy)]-6-acetate, aconitane-6,10-diol
CAS Number
6836-11-9
Molecular Formula
C27H41NO8
Formula Weight
507.6
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:7): 0.12 mg/mlDMSO: 20 mg/mlEthanol: 10 mg/ml
SMILES
CO[C@@H](CC1)C2([C@@](C[C@@]34[H])(O)[C@@](C3([H])OC)([H])[C@]5(C[C@@H]4OC)C6(OCO5)C2N7CC)[C@@]([C@@H]6OC(C)=O)([H])[C@@]1(C7)C
InChi Code
InChI=1S/C27H41NO8/c1-7-28-12-23(3)9-8-17(32-5)26-20(23)21(36-14(2)29)27(22(26)28)25(34-13-35-27)11-16(31-4)15-10-24(26,30)19(25)18(15)33-6/h15-22,30H,7-13H2,1-6H3/t15-,16+,17+,18?,19+,20-,21+,22?,23+,24+,25-,26?,27?/m1/s1
InChi Key
DTTPWCNKTMQMTE-KDBXVETRSA-N
Origin
Plant/Aconitum carmichaelii
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    25 mg

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    Cayman Chemical
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    Product Description

    Deltaline is an alkaloid and a toxin that has been found in D. barbeyi.1,2 It reduces sciatic nerve stimulation-induced compound muscle action potentials (CMAPs) in isolated lizard extensor digitorum longus muscle (IC50 = 156 µM).1 Deltaline (85 mg/kg) increases the number of falls from a beam and decreases the time spent mobile in an open field test, markers of neuromuscular impairment, in mice.2 It also induces lethality in mice (LD50 = 113 mg/kg).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dobelis, P., Madl, J.E., Pfister, J.A., et al. Effects of Delphinium alkaloids on neuromuscular transmission. J. Pharmacol. Exp. Ther. 291(2), 538-546 (1999).

    2. Welch, K.D., Pfister, J.A., Lima, F.G., et al. Effect of α₇ nicotinic acetylcholine receptor agonists and antagonists on motor function in mice. Toxicol. Appl. Pharmacol. 66(3), 366-374 (2013).