Incensole Acetate

Incensole acetate is a diterpene originally isolated from frankincense produced by B. carterii that has diverse biological activities.^1,2,3 It is an activator of transient receptor potential vanilloid 3 (TRPV3) that induces calcium influx in HEK293 cells expressing TRPV3 (EC₅₀ = 16 µM).² Incensole acetate (60-140 µM) inhibits degradation of inhibitor of NF-κB (IκBα) in TNF-α-stimulated HeLa cells.¹ It reduces apoptosis, increases in malondialdehyde (MDA) levels, and the production of reactive oxygen species (ROS) induced by amyloid-β (25-35) peptide (Item No. 24155) in human olfactory bulb neural stem cells (hOBNSCs).³ Incensole acetate (50 mg/kg) reduces paw edema in mice in a model of hind paw inflammation induced by carrageenan.¹ It also increases the time spent in the open arms of the elevated plus maze and reduces immobility in the forced swim test, indicating anxiolytic and antidepressant-like activity, respectively.²

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1. Moussaieff, A., Shohami, E., Kashman, Y., et al. Incensole acetate, a novel anti-inflammatory compound isolated from Boswellia resin, inhibits nuclear factor-κB activation. Mol. Pharmacol. 72(6), 1657-1664 (2007).

2. Moussaieff, A., Rimmerman, N., Bregman, T., et al. Incensole acetate, an incense component, elicits psychoactivity by activating TRPV3 channels in the brain. FASEB J. 22(8), 3024-3034 (2008).

3. El-Magd, M.A., Khalifa, S.F., A Alzahrani, F.A., et al. Incensole acetate prevents beta-amyloid-induced neurotoxicity in human olfactory bulb neural stem cells. Biomed. Pharmacother. 105, 813-823 (2018).