A diterpenoid with TRPC6 inhibitory and analgesic activities
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Isomer(s)
34614Incensole Acetate
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Larixyl Acetate

Item No. 35309

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(αS,1S,4S,4aS,8aR)-4-(acetyloxy)-α-ethenyldecahydro-α,5,5,8a-tetramethyl-2-methylene-1-naphthalenepropanol
CAS Number
4608-49-5
Synonyms
  • Larixol Acetate
Molecular Formula
C22H36O3
Formula Weight
348.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly solubleEthyl Acetate: Slightly soluble
SMILES
C[C@]12[C@@](C(C)(CCC2)C)([H])[C@H](CC([C@@H]1CC[C@](C)(O)C=C)=C)OC(C)=O
InChi Code
InChI=1S/C22H36O3/c1-8-21(6,24)13-10-17-15(2)14-18(25-16(3)23)19-20(4,5)11-9-12-22(17,19)7/h8,17-19,24H,1-2,9-14H2,3-7H3/t17-,18-,19-,21+,22+/m0/s1
InChi Key
WCNCDVQMEQJFGH-TZWCSUAMSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Larixyl acetate is a diterpenoid that has been found in Larix and has transient receptor potential canonical 6 (TRPC6) inhibitory and analgesic activities.1,2 It inhibits the activity of TRPC6 (IC50 = 0.58 µM) and is selective for TRPC6 over TRPC3 (IC50 = 6.83 µM), as well as over nine additional TRP channels at 10 µM.1 Intrathecal administration of larixyl acetate reduces mechanical and cold allodynia in a rat model of neuropathic pain induced by spared nerve injury (SNI).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Urban, N., Wang, L., Kwiek, S., et al. Identification and validation of larixyl acetate as a potent TRPC6 inhibitor. Mol. Pharmacol. 89(1), 197-213 (2016).

    2. Wang, J., Zhao, M., Jia, P., et al. The analgesic action of larixyl acetate, a potent TRPC6 inhibitor, in rat neuropathic pain model induced by spared nerve injury. J. Neuroinflammation 17(1), 118 (2020).