An inhibitor of DYRK3
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GSK626616

Item No. 34621

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5Z)-2-[(2,6-dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-4(5H)-thiazolone
CAS Number
1025821-33-3
Molecular Formula
C18H10Cl2N4OS
Formula Weight
401.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: soluble
λmax
359 nm
SMILES
O=C1/C(SC(NC2=C(Cl)C=CC=C2Cl)=N1)=C/C3=CC4=C(N=CC=N4)C=C3
InChi Code
InChI=1S/C18H10Cl2N4OS/c19-11-2-1-3-12(20)16(11)23-18-24-17(25)15(26-18)9-10-4-5-13-14(8-10)22-7-6-21-13/h1-9H,(H,23,24,25)/b15-9-
InChi Key
RJPNRXFBYZVRIB-DHDCSXOGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $160

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    10 mg

    $268

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    25 mg

    $587

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    Product Description

    GSK626616 is an inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 3 (DYRK3; IC50 = 0.7 nM).1 It enhances erythropoietin-induced erythropoiesis in isolated human bone marrow. GSK626616 increases hemoglobin levels in a mouse model of carboplatin- and radiation-induced anemia.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Erickson-Miller, C.L., Creasy, C., Chadderton, A., et al. GSK626616: A DYRK3 inhibitor as a potential new therapy for the treatment of anemia. Blood 110(11), 510 (2007).