A bile acid and derivative of cholic acid
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Metabolite(s)
30837Nordeoxycholic Acid
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Norcholic Acid

Item No. 34623

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5β)-3α,7α,12α-trihydroxy-24-norcholan-23-oic acid
CAS Number
60696-62-0
Synonyms
  • 23-Norcholic Acid
Molecular Formula
C23H38O5
Formula Weight
394.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: slightly solubleMethanol: slightly soluble
SMILES
C[C@@]12[C@](CC[C@]2([H])[C@@H](CC(O)=O)C)([H])[C@@]3([H])[C@@](C[C@@H]1O)([H])[C@@]4([C@](C[C@@H](CC4)O)([H])C[C@H]3O)C
InChi Code
InChI=1S/C23H38O5/c1-12(8-20(27)28)15-4-5-16-21-17(11-19(26)23(15,16)3)22(2)7-6-14(24)9-13(22)10-18(21)25/h12-19,21,24-26H,4-11H2,1-3H3,(H,27,28)/t12-,13+,14-,15-,16+,17+,18-,19+,21+,22+,23-/m1/s1
InChi Key
SHUYNJFEXPRUGR-RTCCEZQESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    10 mg

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    Cayman Chemical
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    Product Description

    Norcholic acid is a bile acid and 23-carbon derivative of cholic acid (Item No. 20250).1 Levels of norcholic acid are increased in the urine of patients with liver cirrhosis or cerebrotendinous xanthomatosis (CTX), an inborn error of metabolism characterized by a deficiency in the mitochondrial enzyme sterol 27-hydrolylase (CYP27A1) that leads to progressive neurological symptoms.2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nakatomi, F., Kihira, K., Kuramoto, T., et al. Intestinal absorption and metabolism of norcholic acid in rats. J. Pharmacobiodyn 8(7), 557-563 (1985).

    2. Bremmelgaard, A., and Sjövall, J. Bile acid profiles in urine of patients with liver diseases. Eur. J. Clin. Invest. 9(5), 341-348 (1979).

    3. Kuramoto, T., Furukawa, Y., Nishina, T., et al. Identification of short side chain bile acids in urine of patients with cerebrotendinous xanthomatosis. J. Lipid Res. 10, 1895-1902 (1990).

    4. Pilo de la Fuente, B., Sobrido, M.J., Girós, M., et al. Usefulness of cholestanol levels in the diagnosis and follow-up of patients with cerebrotendinous xanthomatosis. Neurologia 26(7), 397-404 (2011).