A pentapeptide involved in the regulation of food intake
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Enterostatin (human, mouse, rat) (trifluoroacetate salt)

Item No. 34624

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-alanyl-L-prolylglycyl-L-prolyl-L-arginine, trifluoroacetate salt
Synonyms
  • APGPR
Molecular Formula
C21H36N8O6 • XCF3COOH
Formula Weight
496.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 25 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
N=C(N)NCCC[C@@H](C(O)=O)NC([C@H]1N(C(CNC([C@H]2N(C([C@H](C)N)=O)CCC2)=O)=O)CCC1)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C21H36N8O6.C2HF3O2/c1-12(22)19(33)29-10-4-6-14(29)17(31)26-11-16(30)28-9-3-7-15(28)18(32)27-13(20(34)35)5-2-8-25-21(23)24;3-2(4,5)1(6)7/h12-15H,2-11,22H2,1H3,(H,26,31)(H,27,32)(H,34,35)(H4,23,24,25);(H,6,7)/t12-,13-,14-,15-;/m0./s1
InChi Key
HMDSUZSIJATJAB-WFGXUCIJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

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    10 mg

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    25 mg

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Enterostatin is an endogenous pentapeptide fragment involved in the regulation of food intake.1 It is released from its precursor protein, procolipase, during digestion and acts in the peripheral and central nervous systems to reduce food, especially fat, intake through the vagus nerve in the periphery and κ-opioid-, serotonin (5-HT) receptor subtype 5-HT1B-, and cholecystokinin-mediated signaling pathways in the brain.1,2 Enterostatin binds to mitochondrial complex V, also known as F1F0 ATP synthase, in a cell-free assay and inhibits ATP production and increases thermogenesis in INS-1 insulinoma cells.3 It reduces body weight in rats fed a high-fat diet but not mice fed a chow diet. Enterostatin (1 nmol, i.c.v) reduces food intake in wild-type, but not melanocortin receptor 4 knockout (Mc4r-/-), mice.4 It also enhances memory consolidation in mice in a passive avoidance test when administered at a dose of 300 mg/kg, an effect that can be blocked by the cholecystokinin 1 (CCK1) receptor antagonist lorglumide (Item No. 17555).5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. York, D.A., and Park, M. Enterostatin, a peptide regulator of dietary fat ingestion. Handbook of biologically active peptides 969-974 (2006).

    2. Lin, L., and York, D.A. 5-HT1B receptors modulate the feeding inhibitory effects of enterostatin. Brain Res. 1062(1-2), 26-31 (2005).

    3. Berger, K., Sivars, U., Winzell, M.S., et al. Mitochondrial ATP synthase—a possible target protein in the regulation of energy metabolism in vitro and in vivo. Nurtr. Neurosci. 5(3), 201-210 (2002).

    4. Lin, L., Park, M., and York, D.A. Enterostatin inhibition of dietary fat intake is modulated through the melanocortin system. Peptides 28(3), 643-649 (2007).

    5. Ohinata, K., Sonoda, S., Shimano, T., et al. Enterostatin (APGPR) enhances memory consolidation in mice. Peptides 28(3), 719-721 (2007).