Isopimpinellin

Isopimpinellin is a furanocoumarin that has been found in H. persicum and has diverse biological activities.^1,2,3 It inhibits lipid peroxidation in a cell-free assay.¹ Isopimpinellin (20 µM) prevents histamine release from, and activation of NF-κB in, RBL-2H3 cells.² It also decreases the secretion of TNF-α, IL-1β, and IL-4 from RBL-2H3 cells. Isopimpinellin prevents benzo[a]pyrene-DNA adduct formation in sensitivity to carcinogenesis (SENCAR) mice when administered at a dose of 70 mg/kg and reduces the number of papillomas initiated and promoted by 7,12-dimethylbenz[a]anthracene (DMBA; Item No. 30383) in SENCAR mice when administered at 30, 70, or 150 mg/kg.³

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1. Souri, E., Farsam, H., Sarkheil, P., et al. Antioxidant activity of some furanocoumarins isolated from Heracleum persicum. Pharm. Biol. 42(6), 396-399 (2004).

2. Li, D., and Wu, L. Coumarins from the roots of Angelica dahurica cause anti-allergic inflammation. Exp. Ther. Med. 14(1), 874-880 (2017).

3. Kleiner, H.E., Vulimiri, S.V., Starost, M.F., et al. Oral administration of the citrus coumarin, isopimpinellin, blocks DNA adduct formation and skin tumor initiation by 7,12-dimethylbenz[α]anthracene in SENCAR mice. Carcinogenesis 23(10), 1667-1675 (2002).