A coumarin derivative with diverse biological activities
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Isomer(s)
34642Isopimpinellin
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Pimpinellin

Item No. 36274

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,6-dimethoxy-2H-furo[2,3-h]-1-benzopyran-2-one
CAS Number
131-12-4
Molecular Formula
C13H10O5
Formula Weight
246.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 5 mg/ml
λmax
223, 242, 249, 272, 313 nm
SMILES
O=C1OC2=C(C=C1)C(OC)=C(OC)C3=C2C=CO3
InChi Code
InChI=1S/C13H10O5/c1-15-11-7-3-4-9(14)18-10(7)8-5-6-17-12(8)13(11)16-2/h3-6H,1-2H3
InChi Key
BQPRWZCEKZLBHL-UHFFFAOYSA-N
Origin
Plant/Psoralea corylifolia
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $62

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    10 mg

    $117

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    25 mg

    $273

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    50 mg

    $486

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    Product Description

    Pimpinellin is a coumarin derivative that has been found in L. dasyanthus and has diverse biological activities.1,2,3 It inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) by 23.54 and 66.55%, respectively, when used at a concentration of 20 µg/ml.1 Pimpinellin (40 mg/kg) inhibits collagen-induced aggregation of mouse platelets ex vivo.2 It inhibits seizure-like behavior induced by pentylenetetrazole (PTZ; Item No. 18682) in zebrafish larvae.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Karakaya, S., Koca, M., Sytar, O., et al. The natural phenolic compounds and their antioxidant and anticholinesterase potential of herb Leiotulus dasyanthus (K. Koch) Pimenov & Ostr. Nat. Prod. Res. 34(9), 1303-1305 (2020).

    2. Liu, G., Yuan, Z., Tian, X., et al. Pimpinellin inhibits collagen-induced platelet aggregation and activation through inhibiting granule secretion and PI3K/Akt pathway. Front. Pharmacol. 12, 706363 (2021).

    3. Kozioł, E., Jóźwiak, K., Budzyńska, B., et al. Comparative antiseizure analysis of diverse natural coumarin derivatives in zebrafish. Int. J. Mol. Sci. 22(21), 11420 (2021).