A sapogenin with enzyme inhibitory and hormone-releasing activities
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Gitogenin

Item No. 34681

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2α,3β,5α,25R)-spirostan-2,3-diol
CAS Number
511-96-6
Synonyms
  • NSC 147752
  • 5α-hydroxy Tigogenin
Molecular Formula
C27H44O4
Formula Weight
432.6
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: 30 mg/ml
SMILES
C[C@@H]1[C@@]2(CC[C@H](CO2)C)O[C@]3([H])[C@@]1([H])[C@@]4([C@@]([C@@]5([H])[C@]([C@@]6([C@@](C[C@H]([C@@H](C6)O)O)([H])CC5)C)([H])CC4)([H])C3)C
InChi Code
InChI=1S/C27H44O4/c1-15-7-10-27(30-14-15)16(2)24-23(31-27)12-20-18-6-5-17-11-21(28)22(29)13-26(17,4)19(18)8-9-25(20,24)3/h15-24,28-29H,5-14H2,1-4H3/t15-,16+,17+,18-,19+,20+,21-,22-,23+,24+,25+,26+,27-/m1/s1
InChi Key
FWCXELAAYFYCSR-RYKNUXCGSA-N
Origin
Plant/Tribulus terrestris L.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $72

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    5 mg

    $251

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    10 mg

    $429

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    25 mg

    $895

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Gitogenin is a sapogenin that has been found in T. foenum-graecum and has enzyme inhibitory and hormone-releasing activities.1,2 It is an inhibitor of UDP-glucuronosyltransferase (UGT) isoform UGT1A4 (IC50 = 0.69 µM).1 Gitogenin (20 µg/ml) stimulates the release of growth hormone in primary rat pituitary cells.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xu, M., Dong, P., Tian, X., et al. Drug interaction study of natural steroids from herbs specifically toward human UDP-glucuronosyltransferase (UGT) 1A4 and their quantitative structure activity relationship (QSAR) analysis for prediction. Pharmacol. Res. 110, 139-150 (2016).

    2. Shim, S.H., Lee, E.J., Kim, J.S., et al. Rat growth-hormone release stimulators from fenugreek seeds. Chem. Biodivers. 5(9), 1753-1761 (2008).