A ROCK2 inhibitor
Related Products
Alternative(s)
38248Chroman 1
Contained In
502884Stem Cell Survival Reagent Kit (CEPT)
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Chroman 1 (hydrochloride hydrate)

Item No. 34682

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(S)-N-(2-(2-(dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)phenyl)-6-methoxychromane-3-carboxamide, dihydrochloride hydrate
Synonyms
  • (S)-Chroman 1
Molecular Formula
C24H28N4O4 • 2HCl [XH2O]
Formula Weight
527.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
CN(C)CCOC(C=C(C1=CNN=C1)C=C2)=C2NC([C@H]3CC4=CC(OC)=CC=C4OC3)=O.Cl.Cl.O
InChi Code
InChI=1S/C24H28N4O4.2ClH.H2O/c1-28(2)8-9-31-23-12-16(19-13-25-26-14-19)4-6-21(23)27-24(29)18-10-17-11-20(30-3)5-7-22(17)32-15-18;;;/h4-7,11-14,18H,8-10,15H2,1-3H3,(H,25,26)(H,27,29);2*1H;1H2/t18-;;;/m0.../s1
InChi Key
RBALUPLYQMKKPT-LPECGTQYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $65

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    5 mg

    $260

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    10 mg

    $423

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    Product Description

    Chroman 1 is an inhibitor of Rho-associated kinase 2 (ROCK2; IC50 = <1 nM).1 It is selective for ROCK2 over protein kinase A (PKA) and Cdc42-binding kinase (MRCKα; IC50s = 1,740 and 127 nM, respectively). Chroman 1 inhibits phosphorylation of myosin light chain (MLC) in a cell-based assay (IC50 = <4 nM). This product is also available as part of Cayman's Stem Cell Survival Reagent Kit (CEPT) (Item No. 502884).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, Y.T., Vojkovsky, T., Fang, X., et al. Asymmetric synthesis of potent chroman-based Rho kinase (ROCK-II) inhibitors. Med. Chem. Commun. 2(1), 73-75 (2011).